About MOTS-c
What is MOTS-c?
MOTS-c (CAS 1627580-64-6) is a 16-amino-acid mitochondrial-derived peptide (sequence MRWQEMGYIFYPRKLR). It is encoded in the mitochondrial 12S rRNA region, not in nuclear DNA. Labs use it to study how mitochondria send metabolic signals to the cell.
Werhner Lab supplies MOTS-c as lyophilised powder in 10 mg vials.
CAS: 1627580-64-6. Molecular weight: ~2174.6 g/mol. Class: mitochondrial-derived peptide (MDP).
How MOTS-c is studied in the literature
Papers place MOTS-c in metabolic-stress, glucose-utilisation, and exercise-mimetic models. Background only.
Cellular energy and metabolic stress
Used in models of AMPK-related energy sensing, metabolic challenge, and mitochondrial-to-nuclear signalling.
Glucose-handling models
Also studied in insulin-sensitivity and skeletal-muscle glucose-use systems.
Within the class — how MOTS-c differs
MOTS-c is not an incretin and not a GH secretagogue. It is a short mitochondrial peptide. That is why it sits in a “copper and mitochondrial” style category next to compounds such as GHK-Cu, not next to tirzepatide.
Research areas
- Mitochondrial peptide biology
- Metabolic-stress and energy-sensing pathways
- Muscle / glucose-utilisation models
- Comparison with other MDPs (e.g. humanin family)
Specifications
| CAS | 1627580-64-6 |
| Sequence | MRWQEMGYIFYPRKLR |
| Molecular weight | ~2174.6 g/mol |
| Class | Mitochondrial-derived peptide |
| Purity | ≥ 97.5% (batch CoA) |
| Form | Lyophilised powder, sealed vial |
| Size | 10 mg |
Storage
Powder: −20°C long term; 2–8°C short term.
Reconstituted: 2–8°C; avoid repeat freeze–thaw.
Quality
Batch CoA on request. Batch example: MC10-2359.
Important notice — Research Use Only
MOTS-c is supplied by Werhner Lab for laboratory research only. Not a medicine or supplement. Not for human consumption.